Archive for 'Norman Marcus'

Ehlers-Danlos (EDS)

Thursday, December 15th, 2016 at 10:36 AM  

It is known that physically active patients who have stiff muscles frequently develop pain.  What is less known is that patients with overly flexible joints will also frequently develop muscle pain.

Congenital diseases, such as Marfan Syndrome and Ehlers-Danlos Syndrome (EDS), may cause joints to repeatedly dislocate, resulting in stiffness in the muscles surrounding the joint – a way that the body attempts to help the unstable joint.  The reflexive stiffness and spasms in the muscles surrounding the unstable joint cause pain.

Treatment to relax the muscles such as injections into trigger points or into the muscle attachments may do too good a job – that is, if the muscles become too relaxed, the joint may become too loose and  continue to dislocate.

An alternative treatment we have used is low level laser therapy (LLLT).  LLLT uses light energy in a narrow wavelength (810-980nm) to deeply penetrate through the skin into the muscles and tendons.  LLLT produces an increase in chemicals in the body (Cytochrome C Oxidase) that enables the production of ATP (adenosine triphosphate) which can aid in healing damaged tissue. Using LLLT to reduce pain in EDS patients has resulted in ~40% decrease in pain lasting for 3-4 weeks (or even longer!) without making the underlying muscle too loose.

Read more about EDS HERE

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What To Do When Back Pain Causes Overdose?

Friday, February 6th, 2015 at 9:00 AM  

“We don’t appreciate what we have until it’s gone.” If only we had a dime for every time we heard this. Perhaps the reason it is such a common expression is the simple truth in it. This certainly applies to our health, but specifically our backs. We probably all take our good health in vain, until something goes wrong. By the time we are in our forties over twenty percent of us experience some form of back pain. And what do we do when we experience pain? Well, unfortunately many people will turn to strong painkillers. This means opioids, morphine-like painkillers. And, while we have written about this topic in the past, there is something new on the horizon. Evzio, the brand name of injectable Naloxone, is a prescription medicine that can block the effects of morphine and related painkillers. Approved by the FDA in April 2014, it allows a patient to quickly treat themselves or be treated by a family member if the patient has overdosed on opioids.Evzio

In the past, Evzio was difficult to obtain due to its high cost. However, recently The Clinton Foundation announced that it has negotiated a lower price for Evzio (see NYT article). This will allow municipalities to more easily purchase this medication, making it more available to those who need it.

It is a sad reality that many people will turn, in desperation, to painkillers as an answer to their aching backs. We, at the Norman Marcus Pain Institute, only use opioids as a last resort. Our method of finding the source of the pain and treating it has eliminated back pain for thousands of patients.. Nevertheless, with the rise of overdoses each year, the increased availability of naloxone to non-medical personnel will allow lives to be saved.

 

 

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Is Looking Good Worth Having Back Pain?

Tuesday, February 3rd, 2015 at 2:08 PM  

There is an old expression, “beauty is pain.” Does it need to be? Is it worth risking your long-term health? Why do women wear high-heeled shoes when they know that looking beautiful in the moment may cause them pain down the road? Scientists from the Universite de Bretagne-Sud recently conducted experiments, which studied the effects of high-heeled women on men. Women who wore higher heels (3-4 inches vs. 2 inch heels) were able to get more men to answer survey questions on the streets and were picked up faster in bars and clubs. These studies show some type of empowerment in women with high-heeled shoes.  heelsKnowing that this empowerment exists, and as fashion has increased the height of heels from 4 inches to 5 inches, we would like to remind you that walking for extended periods in high heels can cause calf tendons to shorten and possibly result in an increase in low back pain.

Here at the Norman Marcus Pain Institute, we see patients that run the gamut of factors causing their back pain. Prevention is always the best treatment; since low back pain affects so many of us a simple intervention is being more conscious of our shoes! While those Manolo Blahniks and Jimmy Choos may be stunning, they may be causing a problem for you down the line. At NMPI, we won’t say don’t wear them, just please, wear them in moderation.

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Why Health Insurances Carriers Should Not Be For Profit Enterprises

Wednesday, December 17th, 2014 at 9:00 AM  

In November, I read this article in The New York Times on How Medical Care Is Being Corrupted. In a nutshell — Insurance carriers have been incentivizing care for more than 20 years by selectively paying for some services whilst denying others.

To successfully address a complicated problem, such as long-standing pain, more than one approach is often most effective albeit initially more expensive. As a Pain Medicine physician, I have witnessed the defunding of the only approach that has been found to be consistently successful (by the Cochrane database for systematic reviews) in addressing patients disabled by chronic back pain: comprehensive multidisciplinary pain treatment centers.

While cost should be a consideration in choosing treatment – it should not be the primary deciding factor. For-profit insurance companies can be effective in helping policyholders fund their medical care but they are constrained by conflicting interests

  1. A moral and ethical obligation to care for policyholders who have purchased a policy to protect their health.
  2.  Shareholders who have invested in the company and expect each quarter to produce a reasonable profit.

If you believe, as I do, that health insurance not be allowed to be a for profit enterprise, join in a national discussion to legislate that all health insurance be not-for-profit. Insurance companies should only exist for the protection of the individual patient.

 

 

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Eating forbidden foods, losing weight and helping your heart

Thursday, September 4th, 2014 at 10:59 AM  

I had dinner with Dr. Robert Atkins years before his untimely death. He ordered a juicy marbleized steak with a baked potato drowning in butter and sour cream. At the time I thought this wasn’t a healthy choice- I was wrong! A front page article in the NY Times earlier this week reports on a large year-long NIH funded study published in the Annals of Internal Medicine supporting the ideas of Dr. Atkins, viz. high fat/ low carbohydrate diets are better for your health than equal calories of high carbohydrate/ low fat diets. You not only lose more weight but your total cholesterol goes down and the good cholesterol (HDLs) goes up. This is a great example of showing us that what we firmly believe to be the truth (i.e. a low fat diet is best for your diet and health) may not be so. An important issue in this study is that both groups lost weight. Calorie restriction does work to lose weight- but it may be easier for some patients who have difficulty dieting, to limit their carbohydrates, still feel satisfied, and lose weight.

vegetables-and-fruits-farmers-marketAs I report in my book End Back Pain Forever, a previous NIH funded study also showed that calorie reduction consistently resulted in weight loss; this new study reaffirms that low carbohydrate/high fat diets are healthier for your heart. In my book I reported that eating plant rather than animal protein/fat was preferable if you were concerned about lowering levels of the bad cholesterol (low density lipoproteins-LDLs). If you’re thinking of becoming a vegetarian- eating a vegetarian diet has been shown to produce the lowest levels of cholesterol and in general to be associated with the lowest BMIs (Body Mass Index, which is a measure of body fat based on weight and height.). The carbohydrates that are most damaging are refined carbohydrates such as found in white flour and sugar. No matter what diet you choose you need to get the minimal amounts of essential minerals and vitamins, therefore always include healthy amounts of fresh fruits and vegetables.

To paraphrase Mark Twain, it’s very easy to diet and lose weight- I’ve done it twenty times; The trick is to keep it off once you’ve lost it. Here are some tips from my book:

1. Increase your physical activity. If you never walk anywhere, start to do that. If you walk two blocks a day, increase it to four. If you go to the gym once a week, increase it to twice a week. The idea is to begin where you are now and increase slowly and steadily. Don’t take on more than you can handle, but work your way up. Make yourself a winner by taking on an achievable goal.

2. Don’t attempt total deprivation. Avoid starvation diets. Your body senses that you are starving, and it adjusts by slowing your metabolism, the rate at which calories are burned. This makes it harder to lose weight. Being able to lose weight and maintain the loss requires changing the way you eat and increasing physical activity. Just as you changed your activity level gradually, do the same with diet. In other words, start slowly. Make one simple change. I recommend to my patients that they stop eating bread and pastries. Some love bread and can’t imagine living without it. They soon learn, though, that after a short while, the craving for bread diminishes and their weight starts to drop. Then stop eating pasta or only allow it (and bread) as a treat; let’s say on Sundays.

3. Learn how many calories are in the food that you eat. When patients tell me that all they eat is salad, but they’re gaining weight, I have to remind them that any sauce or dressing may contain high-calorie ingredients. When you are out at a restaurant, it is best to avoid foods that may hide unwanted calories.

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Is Bad Weather To Blame For Your Lower Back Pain?

Wednesday, August 6th, 2014 at 9:30 AM  

A New York Times article Weather May Not Affect Back Pain, printed mid-July, cited a study showing that weather may not affect back pain. The purpose of the study was to explore the often-heard complaint from patients diagnosed with persistent pain related to muscles and bones (musculoskeletal pain) that weather changes cause an increase in pain. The study was based on an analysis of 993 patients who had seen their physician in 2011-2012 complaining of an episode of sudden back pain. These were not patients with a history of back pain.

So this article does not actually examine patients who already have back pain to see if the pain is increased with bad weather. In my practice, at NMPI, I have patients who can tell me a snowstorm is coming 3 days before it occurs. Although studies of the association between weather and pain are not uniformly supportive of the connection, a study done in 1995 of 558 patients with chronic pain found that 2/3 experienced an increase in pain and most of them prior to the occurrence of the bad weather.

bad weatherI have patients whose pain is so severe with bad weather that they can hardly get out of bed. Although there is no good scientific explanation for this association, some suggestions have been offered. When the barometric pressure falls, the air pressure in a painful joint may continue to be a little higher than the air pressure on the outside of the body, causing an increase in pain. Another explanation is that cold and/or inclement weather decreases the amount of time you are outside and active. Patients with musculoskeletal problems (i.e. muscle pain and arthritis) often feel worse with inactivity. In addition cold weather causes the blood vessels in the hands and feet to constrict, which can decrease the amount of available oxygen, resulting in increased muscle pain.

If your history indicates that bad weather causes an increase in your pain, it is likely that your flare up is most likely not an indicator of physical deterioration. Additional pain can be reasonably treated with increased medication for the brief period of weather related pain.

 

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49 States Adopt Prescription Drug Database to Prevent Prescription Drug Abuse

Monday, August 4th, 2014 at 2:24 PM  

Because of the growing problem of addiction, misuse, and diversion, 49 states have now adopted a state prescription drug database.  You may have read an article recently in The New York Times about Missouri being the only state that has not adopted such a database. In New York, as a prescriber of controlled substances, each time a patient is prescribed any type of controlled substance, I must log into the NYS website to confirm that a patient is not receiving other medications from other doctors.

prescriptionsI found a few patients who had not been honest with me and had received medications from other doctors. Unfortunately, the small occurrence of dishonest behavior has obliged all doctors to be alert for the possible misuse of medication.  At the Norman Marcus Pain Institute, I implement several rules for patients receiving any type of controlled substance from me. Here are a few of them:

•             Only one physician can prescribe all pain medications.

•             Only one pharmacy should be used to obtain all pain related medications.

•             All medications, including herbal remedies and over the counter medications, need to be reported since all medications can interact with one another.

•             Medications must be kept in a safe and secure place, such as a locked cabinet or safe.

 

Following these simple rules will help protect my patients and their families from improper use of pain medication.

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Concerns about the Growing Misuse of Opioids – Prescription Painkillers

Tuesday, July 29th, 2014 at 1:29 PM  

From 1991 to 2009, the number of prescriptions written for the strongest pain medications tripled. These medications are collectively named opioids and include morphine, oxycodone, and hydrocodone.Opioids are a type of pain drug that may cause serious side effects. From 2005 to 2009, the number of emergency room visits for nonmedical use of prescribed pain medication doubled. Therefore, the states and federal governments are acting to try to limit the amount of pain medication being prescribed.

At NMPI, we focus on finding the most effective treatment to relieve our patients’ pain – without surgery, steroid injections, or heavy painkillers. However, when a patient complains of severe pain and is not responding well to other pain medications, stronger, prescription opioids will be given.

 
Pain pills blog-Norman Marcus Pain Institute-blogSome opioids, such as oxycodone, are often combined with Tylenol (acetaminophen) in one pill. Some examples of these combination drugs are Lorcet, Lortab, Norco, Vicodin (are all hydrocodone and acetaminophen), and Percocet (oxycodone and acetaminophen). Most often, severe pain is related to a condition that will improve over time. Ideally, all prescription pain medications should be given only while severe pain persists. Like any medication, there are risks and side effects:

 

• Opioids can make you drowsy – which raises the risk of falling and severe injury
• Opioids when mixed with alcohol, anti-anxiety medication, seizure medication, muscle relaxants, or sleep-aids can be deadly.
• Opioids cause constipation and can lower sex drive.
• Patients can become physically and psychologically dependent on opioids.
• Overtime a patient with chronic pain can develop a tolerance for the opioid and need a higher dosage.

Keep in mind that not all pain requires such strong medication, and most patients with pain can be managed with drugs such as acetaminophen (Tylenol) and aspirin-like drugs, called non-steroidal anti-inflammatory drugs (such as ibuprofen and Naproxen). When taken as directed, these less powerful drugs may be all that you need. (There are potential serious side effects with acetaminophen and NSAIDs, which I will discuss in a future blog.) For certain pains, some drugs are better than others. Sometimes we find that a drug we have been using may not actually be effective. A New York Times article on July 23, 2014 reported that for treating low back pain, acetaminophen was no better than a placebo.

Physicians have a responsibility to properly care for patients in pain. Some of these patients may appear to be at a higher risk to abuse opioids. Occasionally, patients complain of non-existent pain to obtain opioids for its mood-altering affect, called a “high.” The fact is that physicians who had been writing too many prescriptions for pain medication are now wary of prescribing any potentially habit-forming pain drugs. This has resulted in a decrease in emergency room visits for drug overdose and deaths from overdose, but it has also resulted in depriving many patients of medication they legitimately need to function normally.

At NMPI, when we treat patients in pain who have a history of drug abuse or who test positive on a written test to determine the risk of abuse, I believe that these two basic American traditions should be the guiding principles:

1. Innocent until proven guilty; and

2. In the words of Ronald Reagan, Trust but verify. Those patients who have problems or are at risk to not properly use pain medication need extra attention, not condemnation. They may be more difficult to treat, but that is why there are specialists to deal with complex pain problems.

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Morphine: Friend or Enemy?

Wednesday, July 23rd, 2014 at 5:26 PM  

You may have read several articles in the news lately about opioids and pain medications. Earlier in July, The New York Times printed two separate articles on the dangers and abuse of prescriptions drugs in the States. On July 1st, Sabrina Tavernise’s Prescription Overdose Deaths in Florida Plunge After Tough Measures, Report Says, appeared in the Health section and on July 3rd, The Op-Ed editors wrote a piece entitled States and Painkiller Overdoses.

Obviously, the media is very concerned regarding the large number of pain medications being prescribed, the amount of medications being misused and/or diverted, and the adverse effects of the medication, particularly addiction.Pills

Back in the day, alcohol was used as anesthesia for surgeries – patients were given a bottle of bourbon and told to bite the bullet.  Modern medicine introduced Ether and chloroform for surgical procedures and morphine to control the pain after the surgery. Morphine was thought to only be effective by injection, but then we found that morphine tablets and liquid taken by mouth could be just as effective in relieving pain. Morphine was then used for patients with terminal cancer pain. Why not make a dying patient comfortable?

The availability of oral instead of injectable morphine allowed doctors caring for cancer patients to more easily relieve the suffering that many dying cancer patients experienced. If it was good for cancer pain, why not use it for back pain and neck pain? Short acting and long acting morphine-like drugs were developed and a new approach to pain control became the standard of care. Use morphine and other related drugs, such as oxycodone, Oxycontin, Dilaudid, and hydrocodone, and if the patient has more pain, raise the dose of pain medication.

Although overdose could interfere with breathing and cause death, the most troublesome side effect with careful use was thought to be constipation. Other adverse effects of these medications began to be observed, such as addiction and opioid-induced hyperalgesia (when the morphine-like pain medication actually causes more pain).

In addition, people who had been using mind-altering drugs like heroin recognized that they could get the same effect from prescribed medications, which could be cleaner and cheaper. The illicit use of prescription pain drugs is a growing problem in the USA, and are actually the preferred street drug after marijuana.

At NMPI, we only use prescription drugs like oxycodone, Oxycontin, Dilaudid, and hydrocodone to relieve severe pain when patients are unresponsive to our usual therapies. We take a holistic approach to the treatment of pain. Our treatments include:

  • Exercises
  • Muscle/tendon injections (no cortisone or any other steroids are ever injected into the muscle tissue)
  • Low-level laser therapy, which can aide in the healing of damaged muscle tissue and sensitized fibers found in the muscle attachments.
  • Traditional and novel medications, relaxation therapy, and counseling

In the next few blogs, I will discuss the problems arising with prescription drugs for pain relief and what steps are being taken to try to manage this problem.

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Platelet Rich Plasma Injections (PRP) are not effective for Hamstring injuries

Tuesday, July 15th, 2014 at 3:43 PM  

PRP injections have become a frequently used treatment for painful muscle and tendon injuries despite there being no rigorous studies of its effectiveness[1]. PRP involves the drawing of blood from the injured patient, spinning it down to collect the platelets and then injecting the platelets into the injured tissue. The rationale is that platelets will provide growth factors that will make you heal faster.

A study[2] reported on in a letter to the New England Journal of Medicine found that athletes with hamstring injuries recovered no better with PRP than with placebo (a salt water injection). In a randomized double blind controlled study (RCT), in which 80 recreational and professional athletes with hamstring injuries received either PRP or placebo injections, there was no difference in the average amount of time it took for each group to return to normal activities. In other words, in this study, injections with salt water were as effective as the $1600 injection of platelets. It is often difficult to treat pain related to muscles and tendons. For anyone in pain, a suggested treatment that can get you better faster and is offered by respected physicians is hard to resist. The problem is that without carefully studying a new procedure, compared to a similar control treatment, it is not possible to be sure that the new treatment actually works better. This first RCT of PRP for hamstring injuries suggests that it may not be a reasonable approach to painful muscle injuries.

If the assessmeFusion x64 TIFF Filent of muscle pain was a routine part of the physical examination, time, money and suffering could be minimized. At the Norman Marcus Pain Institute, our approach to painful muscles following injury is based on the work of my mentor, Hans Kraus, M.D., President JFK’s physician for the treatment of his back pain. Painful muscles are frequently the result of tension, weakness, stiffness, spasm or altered muscle tissue (usually referred to as trigger points).

At the Norman Marcus Pain Institute, our physical examination tests for all these causes of pain so that the simplest cost effective treatments can be provided prior to using any invasive procedures. Sometimes severe pain is quickly eliminated with our exercise, electrical stimulation and laser protocols that are described in detail in my book End Back Pain Forever. Your pain may require medication and injections, because one size does not fit all.

 

[1] Moraes VY, Lenza M, Tamoki MJ, Faloppa F, Belloti JC. Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database Syst Rev. 2013.

[2] Reurink G, Goudswaard GJ, et al. Platelet-Rich Plasma Injections in Acute Muscle Injury. N Engl J Med. 2014:370:2546-2547.

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Epidural steroids are not effective for spinal stenosis

Thursday, July 10th, 2014 at 1:44 PM  

I have been suggesting for many years that there is an overuse of spinal injections and surgeries for low back and leg pain, so it was no surprise when I read an article in The New York Times (NYT) that reported on a study recently published in the New England Journal of Medicine[1] about patients with spinal stenosis who are frequently treated with a procedure that has been shown to be ineffective. Epidural steroid and lidocaine injections for patients found to have spinal stenosis were no better than epidural injections of lidocaine alone. In chapter 4 of my book End Back Pain Forever I discuss the many reasons for back pain. MRIs and CT scans of the low back will almost always find something such as spinal stenosis or a degenerated or herniated disc even in patients without pain. Therefore the US Institute of Medicine suggests that these imaging studies should not be done routinely since what you find in the study is frequently not the cause of your pain. The most common cause of back pain is muscles and other soft tissue. If you treat the diagnosis you got from the MRI or CT and the actual reason for the pain is muscle, it makes sense that the treatment will frequently fail, which it does!

The NYT report of this relatively large, randomized, double blind, controlled study clearly demonstrates the ineffectiveness of the use of steroids for symptoms attributable to spinal stenosis (narrowing of the canal in the spine which contains the spinal cord) which occurs frequently as we age. The treatments most often provided are epidural steroids to theoretically reduce the inflammation of the nerves being squeezed by the narrow canal, and surgery to widen the canal. Both approaches have a significant failure rate.

At the Norman Marcus Pain Institute we have shown in multiple published articles that one reason why these approaches are ineffective is that the pain in the back and leg may not be the result of the narrowing or other supposed abnormalities seen on the MRI or CT scan. It is well known that very few (in one published article- less than 10%) scans of the low back in adults are read as normal; as many as 40% of adults with no back pain have herniated discs, and 70% have degenerated discs. So it is “normal” to find an abnormality.

B_vertebrae_function_01

Our unique physical examination, utilizes an instrument I developed, reveals that many patients with back and leg pains have areas of muscle tenderness that are the source of their pain yet are overlooked. One study of more than 23,000 patients[2] found that 70-80% of patients with back pain were diagnosed with sprains and strains of muscle and other soft tissue. It’s hard to believe then, armed with this knowledge, that muscle examination and treatment is not part of the typical standard of care for back pain in the USA[3]. If we are to properly address the cause of most back pain, the evaluation and treatment of its muscular causes must be addressed.

 

 

[1] Friedly JL, Comstock BA, Turner JA, et al. A Randomized Trial of Epidural Glucocorticoid Injections for Spinal Stenosis. New England Journal of Medicine. 2014:374:11-21.

[2] Deyo RA, Weinstein JN. Primary care – low back pain. New England Journal of Medicine. 2001:5:363-70.

[3] Chou R, Qaseem A, Snow V, Casey D, Cross JT, Shekelle P, et al. Diagnosis and Treatment of Low Back Pain: A Joint Clinical Practice Guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007;147:478-491.

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Low Level Laser Therapy as promising treatment

Monday, April 21st, 2014 at 9:10 AM  

Low level laser therapy (LLLT) is a promising new treatment for a variety of painful conditions which is believed to reduce inflammation and stimulate healing of wounds.  Interest in the laser first developed when Endre Mester at Semmelweis University noticed that applying the laser to the backs of shaven mice caused hair to regrow faster than those who did not receive laser treatment.[1]  This observation prompted further study into the regenerative effects of the laser first in rats, and then later in humans.

Currently, there aren’t many large-scale studies evaluating the effectiveness of the laser, but smaller studies of the laser for painful conditions show promising results.

A study of 50 patients with knee osteoarthritis reported that the laser was significantly more effective at providing pain relief than transcutaneous electric nerve stimulation (TENS)**.[2]  Similarly, a separate study of 125 patients with knee osteoarthritis reported both an improvement in pain and an increase in function after LLLT.[3]

In a study of patients with temporomandibular disorders, the laser improved pain within 24 hours, with relief lasting at the 180 day follow-up.[4]

Current studies show that the laser is an up and coming, non-invasive, non-painful treatment option, but larger studies are needed to determine the correct dosing, and for which conditions the laser will be most useful.

 

 

 

**TENS (transcutaneous electrical stimulation) – electrodes are applied to the skin, sending an electric current to the nerves in the skin. The nerves then transmit a signal to the brain. This signal is competing with the signal coming from your painful area. So, instead of feeling your normal pain, you’ll feel a buzzing sensation where the electrodes are attached.


[1] Chung, Hoon, Tianhong Dai, Sulbha K. Sharma, Ying-Ying Huang, James D. Carroll, and Michael R. Hamblin. “The Nuts and Bolts of Low-level Laser (Light) Therapy.” Annals of Biomedical Engineering 40.2 (2012): 516-33. Print.

[2] Kędzierski, Tomasz, Katarzyna Stańczak, Kamila Gworys, Jowita Gasztych, Marcin Sibiński, and Jolanta Kujawa. “Comparative Evaluation of the Direct Analgesic Efficacy of Selected Physiotherapeutic Methods in Subjects with Knee Joint Degenerative Disease – Preliminary Report.” Ortopedia Traumatologia Rehabilitacja 14.6 (2012): 1-10. Print.

[3] Gworys, Kamila, Jowita Gasztych, Anna Puzder, Przemysław Gworys, and Jolanta Kujawa. “Influence of Various Laser Therapy Methods on Knee Joint Pain and Function in Patients with Knee Osteoarthritis.” Ortopedia Traumatologia Rehabilitacja 14.3 (2012): 269-77. Print.

[4] Pereira, T. S., O. D. Flecha, R. C. Guimaraes, A. M. Botelho, JC Ramos Gloria, and K. T. Aguiar Tavano. “Efficacy of Red and Infrared Lasers in Treatment of Temporomandibular Disorders–a Double-blind, Randomized, Parallel Clinical Trial.” Cranio : The Journal of Craniomandibular Practice 32.1 (2014): n. pag. Ovid. Web.

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How antidepressant medication can affect your pain

Wednesday, March 26th, 2014 at 10:36 AM  

Many patients with chronic pain become depressed; therefore it is not surprising that many of these patients will receive antidepressant medications. What is very interesting is that these antidepressants not only can decrease depression associated with pain, but they can also decrease pain itself. They are frequently used to treat persistent pain associated with problems in nerves. The reason that antidepressants are effective for pain is that the chemicals in the nervous system that are associated with depression also are associated with pain.

Pain pills blog-Norman Marcus Pain Institute-blog

Antidepressants increase the available amounts of chemicals which affect your mood.  These chemicals include serotonin, norepinephrine, and dopamine.  The two most common types of antidepressants are:

  1. SSRIs (Serotonin Specific Reuptake Inhibitors) – Antidepressants which only increases the amount of serotonin available.  Examples of SSRIs are escitalopram (Lexapro), fluoxetine (Prozac), citalopram (Celexa), and sertraline (Zoloft).
  2. SNRIs (Serotonin/Norepinephrine Reuptake Inhibitors) – Antidepressants which increase the amount of serotonin and norepinephrine available.  Examples of SNRIs are venlafaxine (Effexor) and duloxetine (Cymbalta).  Examples of Tricyclic Antidepressants (a type of SNRI) are amitriptyline (Elavil), and nortriptyline (Pamelor).

SSRIs are not as effective for pain relief as SNRIs.

Even though the antidepressants may help diminish pain, their side effects can be unacceptable.  A recent review found that although approximately 1/3 of patients who took antidepressants for neuropathic pain experienced moderate pain relief or better, 1/5 discontinued use due to adverse side effects.[1]

Common side effects of antidepressants are nausea, dizziness, insomnia, weight gain/loss, dry mouth and diminished interest in sex (decreased libido). If you’re not having reasonable pain relief with one of these medications, it should not be continued.


[1] Saarto, T., and P. J. Wiffen. “Antidepressants for Neuropathic Pain: A Cochrane Review.” Journal of Neurology, Neurosurgery & Psychiatry 81.12 (2010): 1372-373. Print.

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Case Study: Low Level Laser Therapy

Wednesday, March 12th, 2014 at 10:35 AM  

Gregory is a 29 year old manager whose job requires that he travel often.  He came to see me for pain at the back of the left side of his neck which he often felt upon waking up, and during or after jogging over the past 4-5 years.  An MRI showed that his neck did not have any significant spinal abnormalities that might be causing his pain, but a physical examination revealed three muscles that were likely the source of his pain.

I began treating Gregory with a 15 watt class 4 laser.  On his second day of treatment, he reported that he felt no pain in the left side of his neck when he woke up, but that the pain had moved to the right side of the neck and shoulder.  I continued treating the left side of his neck, and also began to treat the right side with the laser.

When he returned for the third day of treatment, the pain in the left side of his neck was completely gone, and the right side’s discomfort was significantly reduced.  At a two month follow-up, his pain was gone.

He is now able to go jogging without any pain in his shoulders or neck.  By starting with a conservative treatment approach, Gregory was able to avoid invasive or costly procedures, and regain function.

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Treating trigger points in muscles

Monday, February 17th, 2014 at 9:30 AM  

The most common method in treating trigger points is with trigger point injections. Simply put, trigger point injections are needles being placed into the taut, tender points of the muscle. However, there are different techniques in injecting the muscle fibers.

There are two major types of needles used in injecting the muscle. With dry needling, it is common to use acupuncture needles[1], which are small, thin and flexible. When a liquid is injected in the muscle (such as saline or lidocaine), hypodermic needles are used, which is a hollow needle that is generally thicker and is not flexible.

Different fluids (injectates) can be used in trigger point injections. Lidocaine or bupivacaine are commonly used, which are numbing agents. Corticosteroids and botulinum toxin (better known as Botox) are also used, in hopes that the injectate would reverse the changes in the trigger point rather than just the needle causing minor damage and inflammation which is thought to lead to regrowth of normal muscle fibers. Still others have used saline. Studies have shown that it didn’t matter what was injected into the muscle[2]; there was not a noticeable difference in pain relief between the different injected substances. Also, dry needling injections seem to be just as effective as injections with any substance, suggesting that what is injected is not what causes relief but rather the physical needling of the muscle.

Other treatments used for trigger points include:

-TENS (transcutaneous electrical stimulation) – electrodes are applied to the skin, sending an electric current to the nerves in the skin. The nerves then transmit a signal to the brain. This signal is competing with the signal coming from your painful area. So, instead of feeling your normal pain, you’ll feel a buzzing sensation where the electrodes are attached.

-“spray and stretch” – a technique in which ethyl chloride spray (or a comparable cold) is used to numb a painful area, followed by gentle stretching

-ultrasound

-low level laser

The fact that so many different approaches claim to be effective indicates that there is confusion concerning the understanding and treatment of pain thought to be coming from trigger points.  All muscle pain is not caused by trigger points.  My associates and I discuss the need for a comprehensive approach to muscle pain in a study published in Pain Medicine[3]. (This article can be accessed here.

 

 

[1] Mense, Siegfried, and Robert Gerwin. Muscle Pain: Diagnosis and Treatment. Heidelberg: Springer, 2010

[2] Cummings, T.Michael, and Adrian R. White. “Needling Therapies in the Management of Myofascial Trigger Point Pain: A Systematic Review.” Archives of Physical Medicine and Rehabilitation 82.7 (2001): 986-92.

[3] Marcus, Norman J., Edward J. Gracely, and Kelly O. Keefe. “A Comprehensive Protocol to Diagnose and Treat Pain of Muscular Origin May Successfully and Reliably Decrease or Eliminate Pain in a Chronic Pain Population.” Pain Medicine 11.1 (2010): 25-34.

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What are trigger points?

Wednesday, February 12th, 2014 at 9:39 AM  

Have you ever felt a painful tightness that just won’t go away no matter how much you stretch? Even if the pain subsides or goes away temporarily, when it recurs you still feel a tender knot that’s always in the same area. This may be due to trigger points (TrPs).  TrPs are tender nodules which can cause pain and are found in a taut band of muscle tissue.  This taut band is formed from a small group of contracted muscle fibers which will make that region of your muscle feel hard and tender.  TrPs are sensitive to pressure and movement. Pressing on a trigger point will cause pain.

Muscle Fiber

TrPs can be classified as either active or latent.  A latent TrP is one that causes pain when palpated, or pressed on, but not spontaneously while resting.  An active TrP can cause spontaneous pain – either at rest, in use, or while being pressed.  If there is enough stress – for example, from too much exercise, a latent TrP can transform into an active TrP.

The cause of TrPs is still being studied, however, there is speculation that the taut band appears in the muscle first without any tenderness or irritation.  With additional stress, the hardened area becomes tender to the touch (a latent TrP), and finally, may progress to producing spontaneous pain as an active TrP.  The initial hardness in a band of muscle fibers can be caused my multiple factors:  injury, overstretching, or over-exercising.

TrPs can be a debilitating source of pain. They can cause weakness and lack of coordination in the muscles where they are found. Next blog, we will discuss common treatment options for trigger points.

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Muscles as the source of pain

Monday, February 3rd, 2014 at 1:03 PM  

Muscles are the largest organ system in the body, accounting for approximately 50% of our body weight.  We have different ways of categorizing muscles: how they look, how they move, and where they’re located. We are going to focus on muscles that move voluntarily, which means we tell the muscles to move, as opposed to involuntary muscles, which automatically move on their own (like our heart and blood vessels). There are 641 muscles in the body – 340 pairs (meaning we have one on the right, and one on the left), and one unpaired (which is the transverse arytenoid for those who must know).

Back Pain

70% of lower back pain is diagnosed as idiopathic or non-specific[1], which means we are not sure what caused the pain. However, most investigators believe that sprains and strains of the soft tissue are the source of pain. Soft tissue refers to muscles, tendons, and ligaments. So it may be surprising that the emphasis in evaluating and treating lower back pain, neck pain, and shoulder pain, is on the spine and the nerves coming out of the spine. In fact, from 1997 to 2005, the prevalence of the diagnosis of spine-related issues has increased 100% while the diagnosis of strains and sprains of soft tissue has gone down by 40%[2].

This is generally attributed to the increase in the use of high-tech imaging studies, such as MRI and CT scans.  However, just because we have a clearer image of what’s going on inside of your body doesn’t mean that we have a clearer understanding of what’s causing your pain. More than 90% of lower spine MRIs exams in adults are abnormal[3]. Studies have found that up to 40% of people have herniated discs and as many as 70% have degenerated discs with no pain. If people can walk around with abnormal spines without pain, then this means that abnormalities in the spine aren’t always the cause of pain. Your diagnosis of a herniated disc, spinal stenosis, or spondylosisthesis may actually be unrelated to your source of pain.

Muscles are often ignored when it comes to diagnosing pain. I believe the reason is that we rarely evaluate muscles as a source of pain. We generally don’t learn about or understand how they work, what chemical changes take place inside, and how they produce pain (the pathophysiology). I would like to take the next few blogs to discuss how muscles contribute to your chronic pain.


[1] Deyo, RA., et al. Low Back Pain. NEJM. 2001; 344(5):363-370

[2] Martin, B., et al. Expenditures and health status among adults with back and neck problems. JAMA. 299(6):656-64, Feb 2008.

[3] Zimmerman, Robert D. “A Review of Utilization of Diagnostic Imaging in the Evaluation of Patients with Back Pain: The When and What of Back Pain Imaging.” Journal of Back and Musculoskeletal Rehabilitation 8 (1997): 125-33.

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